A paramedic sent to Michael Jackson's mansion said he saw his doctor scoop up three bottles of lidocaine and place them in a bag as efforts were made to revive the pop superstar.
Martin Blount told a court in Los Angeles he was surprised to see the bottles because Dr Conrad Murray had denied giving Jackson any drugs.
Mr Blount said the physician also produced a hypodermic needle at one point but he and fellow paramedics refused to let him use it.
He described Dr Murray as "frantic" and said he was sweating profusely.
The paramedic was giving evidence at a preliminary hearing into Michael Jackson'sdeath on June 25, 2009
On Wednesday another paramedic Richard Sennef said Jackson appeared lifeless when he first laid eyes on him.
He said Dr Murray claimed he was treating the singer for dehydration and exhaustion and he had just passed out.
But Mr Sennef said he did not believe him. He said his legs were cold and limp and his eyes dried out, while his hands and feet were turning blue.
He said he looked more like a hospice patient than an international pop superstar about to embark on a series of concerts.
Alberto Alvarez says he was told to put away drug vials before calling 911
Earlier Jackson's bodyguard claimed Dr Murray had ordered him to put controversial medicines away in a bag before calling 911.
Alberto Alvarez was the first security guard to reach the bedroom where prosecutors say Dr Murray gave Jackson a fatal dose of the anaesthetic propofol.
An emotional Mr Alvarez, 34, said he was "frozen" by the sight of Jackson on the bed with his eyes and mouth open.
"I was reaching for phone to call 911 when children came into the room. Paris screamed 'Daddy', started crying. Murray said 'get them out'," Alvarez said.
"He just grabbed a handful of bottles, or vials, and he instructed me to put them in a bag."
Conrad Murray denies doing anything wrong
Prosecutors claim Dr Murray administered propofol without the proper equipment, then tried to cover up his actions after Jackson died.
Deputy District Attorney David Walgren said in his opening statement it was at least another 21 minutes before Dr Murray sent for paramedics.
Jackson was rehearsing for a run of concerts in London
A judge will examine all the evidence and decide if there are sufficient grounds for Dr Murray to stand trial for involuntary manslaughter.
The Houston-based cardiologist, who was hired by Jackson as he prepared for a series of 50 concerts at the O2 Arena in London, denies all the charges.
